Peering into their crystal telescopes, the world's leading scientists see a magnificent future:

* "The use of proteins and other markers [will] permit the early detection and identification of cancer, hugely increasing the prospects of survival."

* "Young adults alive today will, on average, live to 120."

* "Eternal life may come within our reach once we understand enough about how our knowledge and mental processes work ... to duplicate that information -- and then [transfer it] into more robust machines."

* "Someone who is already alive will be the first person to make their permanent home off-Earth."

* "Within a generation ... we will be able to make self-replicating machines that ... absorb energy through solar cells, eat rock and use the energy and minerals to make copies of itself ... [as well as] toasters, refrigerators, and Lamborghinis."

Those are just five of the gee-whiz prognostications offered in response to the 10th Annual Edge Question, posed by John Brockman, editor of the science web site www.edge.org [4]. This year, Richard Dawkins [5], Steven Pinker [6], Jared Diamond [7], Freeman Dyson [8] and J. Craig Venter [9] were among the 160 luminaries who in short, clear essays, tackled the question "What are you optimistic about?"

Forcing respondents to set aside the doom-and-gloom mindset that passes for sophistication, Brockman elicited answers that remind us that we are living in a Golden Age of discovery. The biologists, physicists and computer scientists he queried believe that the 20th-century breakthroughs that have enabled us to live longer, healthier and more comfortable lives may be dwarfed by the accomplishments on the near horizon. ...

The overriding hope among Edge respondents is that our increased capacity to gather and analyze information will spark the rise of an "evidence-based" world. We see this already in the field of criminal justice, where people convicted on faulty "eyewitness" testimony have been freed thanks to DNA. In the future, respondents argue, the instincts and perceptions that inform so much of our political, legal and cultural decision-making will be replaced by hard facts.

"We will learn more about the human condition in the next two decades than we did in the last two millennia, and we will then begin to apply what we learn, everywhere," writes Clay Shirky [10] of NYU's Graduate School of Interactive Telecommunications Program. "Evidence-based treaties. Evidence-based teaching. Evidence-based industrial design. Evidence-based parenting."

These are exciting times. Next week I'll write about why I'm optimistic, and I'd love to hear from you. Please phone or e-mail and let me know: What are you optimistic about? ... [3]