The best men really do outperform the best women, drugs should be used to enhance our mental powers, and marriages suffer from a “four year itch”, not a seven year one.

These are among the provocative ideas put forward today by leading figures who have been asked what has changed their minds about some of the biggest issues.

The poll of Nobel laureates, scientists, futurists and creative thinkers is published by John Brockman, the New York-based literary agent and publisher of The Edge website.

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