"The main reason I have not sent you a question is that I can not think of one worth sending. So maybe my appropriate question is 'What question should I ask?' The one I wish I could identify would be of great intellectual or practical interest, and I (or someone) would have some hope of solving it. Peter Medawar once defined science as 'the art of the soluble'. This is an example of a definition that may be formally correct but does not help anyone trying to find out what science is, but it makes a good point. For a problem to be scientifically important it has to be soluble. How many angels can dance on a pinhead may be a problem of great interest to some people, but it is not soluble."
To arrive at the edge of the world's knowledge, seek out the most complex and sophisticated minds,
put them in a room together, and have them ask each other the questions they are asking themselves.