To arrive at the edge of the world's knowledge, seek out the most complex and sophisticated minds,
put them in a room together, and have them ask each other the questions they are asking themselves.
Links:
[1] http://www.edge.org/news/john-brockman-matchmaking-with-science-and-art
[2] http://tinyurl.com/6abcc8p
[3] http://www.wired.co.uk/magazine/archive/2011/03/start/matchmaking-with-science-and-art