To arrive at the edge of the world's knowledge, seek out the most complex and sophisticated minds,
put them in a room together, and have them ask each other the questions they are asking themselves.
Links:
[1] http://www.edge.org/news/the-reason-we-reason-in-the-most-recent-edition-of-edgeorg-there%E2%80%99s-a-great-conversation-with
[2] http://tinyurl.com/4yaskm5
[3] http://www.wired.com/wiredscience/2011/05/the-sad-reason-we-reason/