To arrive at the edge of the world's knowledge, seek out the most complex and sophisticated minds,
put them in a room together, and have them ask each other the questions they are asking themselves.
Links:
[1] http://www.edge.org/news/science-straight-from-the-source
[2] http://is.gd/Xi2UTR
[3] http://www.newscientist.com/blogs/culturelab/2011/08/science-straight-from-the-source.html