To arrive at the edge of the world's knowledge, seek out the most complex and sophisticated minds,
put them in a room together, and have them ask each other the questions they are asking themselves.
Links:
[1] http://www.edge.org/news/fronteira
[2] http://is.gd/FvmM4r
[3] http://www.edge.org/conversation/who-gets-to-keep-secretshillis-39s-question-an-edge-nbspspecial-event
[4] http://www.edge.org/documents/press/oglobo2010.html